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GLP-1 S (Semaglutide) is a long-acting GLP-1 (glucagon-like peptide-1) receptor agonist research peptide widely used to study GLP-1R-mediated signaling, glucose homeostasis, appetite regulation, and downstream cardiometabolic biology. Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1 and is engineered for extended activity via albumin binding, enabled by position 26 lysine modification with a hydrophilic spacer and a C18 fatty di-acid. It is also modified at position 8 to improve stability against DPP-4 enzymatic degradation, supporting sustained receptor engagement in experimental settings.GLP-1 S
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